What is Letrozole (Femara)?

Letrozole (brand name: Femara) is an aromatase inhibitor used primarily in the treatment of hormone receptor-positive breast cancer in postmenopausal women. It works by reducing estrogen production in the body, slowing or stopping the growth of estrogen-dependent cancer cells.

Letrozole is also sometimes used off-label to treat infertility in women by inducing ovulation.

• Generic name: letrozole
• Brand name: Femara
• Drug classes: Aromatase inhibitors, hormonal therapy agents

Warnings

• Letrozole is not recommended for premenopausal women unless specifically prescribed by a doctor for certain conditions.
• Do not use letrozole during pregnancy, as it may cause harm to the fetus.
• Letrozole may decrease bone mineral density, increasing the risk of osteoporosis or fractures.
• Inform your doctor if you have a history of liver disease, kidney disease, or high cholesterol.

Before Using This Product

• Do not use letrozole if you are allergic to it or any of its components.
• Inform your healthcare provider if you have osteoporosis or are at risk of bone density loss.
• Discuss any current medications, supplements, or health conditions with your doctor, as these may interact with letrozole.
• Do not use letrozole if you are pregnant or breastfeeding.

How Should I Take Letrozole (Femara)?

• Dosage: The typical dose is 2.5 mg taken orally once daily.
• With or Without Food: Letrozole can be taken with or without food.
• Duration: Treatment duration may vary, often prescribed for 5 years or more in breast cancer treatment.

What Happens If I Miss a Dose?

• Take the missed dose as soon as you remember, unless it is close to the next scheduled dose.
• If it is almost time for the next dose, skip the missed dose and continue with your regular schedule.
• Do not double doses to make up for a missed dose.

What Happens If I Overdose?

• Symptoms of overdose are uncommon but may include nausea, vomiting, or dizziness.
• Seek emergency medical attention if you suspect an overdose.

What to Avoid

• Avoid using estrogen-containing products, as they may interfere with the effectiveness of letrozole.
• Avoid excessive alcohol consumption, which may worsen side effects like bone density loss or liver strain.
• Avoid driving or operating heavy machinery if you experience dizziness or fatigue while taking letrozole.

Letrozole Side Effects

Common side effects may include:

• Hot flashes
• Joint or muscle pain
• Fatigue
• Headache
• Bone pain

Seek immediate medical attention if you experience severe or unusual symptoms, such as:

• Severe chest pain or shortness of breath
• Swelling in the hands, feet, or legs
• Signs of liver problems, such as yellowing of the skin or eyes (jaundice)
• Severe allergic reactions, such as swelling of the face, lips, or tongue